Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review
نویسندگان
چکیده
Hypertension elevates the risk of heart disease and stroke which are one most frequent causes death. Fortunately, hypertension is manageable with use anti-hypertensives a healthy lifestyle. However, patient non-adherence to prescribed dosing regimen primary reason for uncontrolled blood pressure levels. Daily multiple doses medication major reasons non-compliance regimen. Multiple result low solubility high first-pass metabolism anti-hypertensives. There several approaches improve bioavailability like polymeric non-polymeric enhance solubility, avoiding through alternate routes drug delivery others. The objective this review discuss different oral anti-hypertensive drugs.
 Keywords: Solubility enhancements, solid lipid nanoparticles, hot melt extrusion, delivery, pharmacokinetics, poorly soluble, bioavailability.
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2023
ISSN: ['2250-1177']
DOI: https://doi.org/10.22270/jddt.v13i5.5814